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KMID : 1035620150030040288
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Allergy Asthma & Respiratory Disease
2015 Volume.3 No. 4 p.288 ~ p.293
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Effectiveness of premedication and rapid desensitization in hypersensitivity to L-asparaginase
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윤다혜:Yoon Da-Hye
강성희:Kang Sung-Hee/김환수:Kim Hwan-Soo/이재욱:Lee Jae-Wook/윤종서:Yoon Jong-Seo/정낙균:Chung Nack-Gyun/조빈:Cho Bin
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Abstract
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Purpose: L-asparaginase is a crucial chemotherapeutic agent for the treatment of acute lymphoblastic leukemia. However, hypersensitivity to L-asparaginase is common which limits its clinical use.
Methods: We performed 44 cases of premedication and 3 cases of desensitization in 16 patients with hypersensitivity to L-asparaginase.
Results: With premedication, 33 cases completed L-asparaginase injection with no hypersensitivity reactions. Eleven cases showed mild hypersensitivity reactions, such as urticaria. Desensitization was performed in 3 cases: in 2 cases, desensitization was successful, and in 1 case the medication was switched to Erwinia asparaginase.
Conclusion: Premedication and desensitization appear to be useful in helping patients receive desired doses of L-asparaginase in pediatric patients with acute lymphoblastic leukemia.
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KEYWORD
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Asparaginase, Drug hypersensitivity, Premedication, Immunologic desensitization, Acute lymphoblastic leukemia
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